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Nonsteroidal Anti-Inflammatory Drug use and Alzheimer-Type Pathology in Aging Neurol 50:986-990, Mackenzie,I.&Munoz,D.G., 1998 See this aricle in Pubmed Article Abstract Anti-inflammatory drugs have been suggested as a possible treatment for Alzheimer's disease(AD).The association of immune proteins and immune- competent microglial cells with senile plaques(SP)in both AD and normal aging suggests that these drugs may be able to modify the course of AD, either by interfering with SP formation or by suppressing the inflammation associated with SP.We compared postmortem brain tissue from elderly, nondemented,arthritic patients with a history of chronic nonsteroidal anti-inflammatory drug(NSAID)use(n=32,age 77 plus 7 years)and nondemented control subjects with no history of arthritis or other condition that might promote the regular use of NSAIDs.These results suggest that if NSAID use is effective in treating AD,the mechanism is more likely to be through the suppression of microglial activity than by inhibiting the formation of SP or neurofibrillary tangles.

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(click to filter results - removes previous filter) Alzheimer's disease Alzheimer's disease,treatment of dementia dementia,treatment of neuropathology neuropathology,brain neuroprotective agents nonsteroidal anti-inflammatory drug treatment of neurologic disorder

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